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One day makes a big difference!! 

Day 

1

2

3

4-5

6-7

8-10

Contractures 

Beginning 1*

​

Skeletal Muscle 

atrophy begins 1*

​

Pressure area develop 

​

Plasma volume begins to develop 2*

​

Orthostatic hypotension begins to develop 2*

​

Hypoxemia 2*

​

Insulin resistance ^

3*

​

Altered triglyceride levels 4*

​

Increase CA+ in urine 1* 

To-Do List

Get Milk

Pick Up kids

Mobilize Patients 

Sarcopenia (loss of muscle strength) 1-3% per day 1,2*

​

Dorsal atelectasis begins

​

Thoracic fluid volume ^ 5* 

​

Loss of calcium in urine and increased risk of renal calculi

​

40% chance of becoming incontinent if >65 years 6*

​

Peristalsis/impaction <

​

​

8-10% loss of plasma volume 1*

​

Cardiac workload ^ 1*

​

HR (rest) 1*

​

Stroke volume < 1*

​

Cardiac output <1*

​

Lower pain threshold 

​

Anxiety and fear

​

Depressed central nervous system responses

Risk of gastric aspiration and endotoxemia ^

​

Micrrovascular dysfunction 1*

​

> 1% bone mineralization lost per week 6*

​

Visible weakness in 25-30% MV patients 

​

10% decrease in Muscle strength 1*

​

​

Bone degradation continues as long as bed rest occurs

​

Risk of ventilator acquired pneumonia increases every day

​

Risk of long term disabling weakness continues every day 

​

Risk for falls and delirium increases every day

1. DeJonghe B, Sharshar T, Lefaucher JP et al. Paresis acquired in the ICU. A Prospective Multi-Center Study. JAMA 2002; 288(22): 2859-2867

2. King L. Developing a Progressive Mobility Activity Protocol. Orthopedic Nursing 2012; (Sept/Oct) 31(5): 253-262

3. Casey C. The Study of Activity. An Integrative Review. Journal of Gerentological Nursing, 2013; 39(8).

4. Greenleaf JE. Physiology of prolonged Bedrest. NASA Technical Memorandum, 101010.1988

5. Pavy-Le Traon A,  Heer M, Narici MV, Rittweger J, Vernikos J. From Space to Earth: advances in human physiology from 20 years of bed rest studies (1986-2006). Eur J Appl Physiol 2007; 101(2): 143-194

6. Ray K, Boderham A, Paramasivam E. Pulmonary Atelectasis in Anesthesia and Critical Care. Continuing Education in Anaesthesia, Critical Care & Pain j 2014; 14(5): 236-245

7. Hamburg NM, McMackin CJ, Huang AL, Sherouda SM, et al. Physical Inactivity Rapidly induces insulin resistance and microvascular dysfunction in healthy volunteers. Arterioscler. Thromb. Vasc. Biol. 2007; 27:2650-2656

8. Peddie MC, Bone JL, Rehrer NJ, Skeaff CM, Gray AR, & Perry TL. Breaking Prolonged sitting reduces postprandial glycemia I healthy normal-weight adults: a randomized crossover trial. Am J ClinNutr 2013; 98:358-66

9. http://www.ahrq.gov/research/HC/pressureulcertoolkit/putool.htm

10. Stuempfle KJ, & Drury DG. The Physiological Consequences of Bed rest. JEPOnline 2007; 10(3):32-41

11. Vollman K. Progressive Mobility in the Critically Ill. Critical Care Nurse, 2010; 30(2): S3-S4.

12. Winkelman C. Bed Rest In Health and Critical Illness. A Body Systems Approach. AACN Advanced Critical Care 20(3):254-266.

13. Knight J, et al. Effects of bedrest 1. Cardiovascular, respiratory, & hematological systems. Nursing Times 2009; 105(21). https://www.pubfacts.com/detail/19548502/Effects-of-bedrest-1:-cardiovascular-respiratory-and-haematological-systems

14. Nigam Y, Knight J, & Jones A. The physiological effects of bed rest and immobility part 3- the musculoskeletal system, skin, and Immunity. Nursing Times 2009; 105(23):18-22

15. Shearer WT,  Ochs HD, et al. Immune responses in adult female volunteers during the bed-rest model of spaceflight: Antibodies and cytokines. J Allergy Clin Immunol 2009; 123(4): 900–905

16. Anastasopoulos et al. Is plasma calcium concentration implicated in the development of critical illness polyneuropathy and myopathy? Critical Care 2011, 15:R247http://ccforum.com/content/15/5/R247

17. Puthucheary ZA, Rawal J, McPhail M, Connolly B, et al. Acute skeletal muscle wasting in critical illness. JAMA 2013; 310(15)1591–1600. doi:10.1001/jama.2013.278481

18. Kortebein P, Ferrado A, Lombieda J, Wolfe R, & Evans J. Effect of 10 days of bedrest on skeletal muscle in healthy older adults. Journal of the American Medical Association, 2007. 297(16): 1772-1774. doi:10.1001/jama.297.16.1772-b.

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